CDO1 and acute myeloid leukemia: Similarly, inhibiting CDO1 in osteolineage cultures from MSCs derived from patients with AML impaired survival and colony-formation of co-cultured AML cells from the same patient by 2- to 3.2-fold (Fig. 2h,i and Extended Data Fig. 5h), indicating that taurine produced by osteolineage cells promotes LSC growth and survival.