KL and obesity due to melanocortin 4 receptor deficiency: Regarding combination status, there was a significant negative association between Klotho and the hazard ratio (HR) of all-cause mortality in populations with the comorbidities of CVD and T2DM, CVD and obesity, CVD and CKD with HRs (95%CI) of 0.23 (0.06, 0.93), 0.20 (0.06, 0.70) and 0.25 (0.05, 0.97), respectively.