For individual diseases, in the fully adjusted model, higher Klotho levels were significantly associated with lower overall mortality risk only in individuals with CVD, general obesity, and CKD (HR (95% CI): CVD, 0.34 (0.13, 0.85); general obesity, 0.38 (0.17, 0.82); CKD, 0.42 (0.20, 0.90)). This evidence concerns the gene KL and chronic kidney disease.