The anti-obesity activity of anthocyanins was mainly attributed to the suppression of the respective genes involved in lipogenesis and adipogenesis via downregulating the expression of NF-kB, PI3K, vascular endothelial growth factor 2 (VEGRF 2), β-catenin, Akt1, PPARγ, CCAAT, C/EBPα, aP2 (fatty acid-binding protein), FAS, and lipoprotein lipase (LPL)133. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.