In support of the latter, the DIAPH1 gene resides within the region of chromosome 5q31, which is commonly lost in myelodysplastic syndrome (MDS)54 and mice with heterozygous or homozygous loss of mDia1 (the mouse homolog of DIAPH1) develop MDS phenotypes with age55,56. Here, DIAPH1 is linked to myelodysplastic syndrome.