The impaired post-Golgi membrane traffic of activated STING or dysfunction of the ESCRT complex results in the prolonged inflammatory signals, which may be associated with a variety of autoinflammatory and neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) (McCauley et al., 2020) and hereditary spastic paraplegia (HSP) (Farazi Fard et al., 2019; Gu et al., 2020; Lin et al., 2019; Zivony-Elboum et al., 2012). The gene discussed is STING1; the disease is amyotrophic lateral sclerosis.