Recent studies unveil the close association of STING to various autoinflammatory and neurodegenerative diseases including Parkinson’s disease (Sliter et al., 2018), ALS (McCauley et al., 2020; Yu et al., 2020), Niemann-Pick disease type C (Chu et al., 2021), and aging-related diseases (Gulen et al., 2023; Hamann et al., 2019). Here, STING1 is linked to amyotrophic lateral sclerosis.