Tspan7 expression in the iWAT and eWAT of 38-week-old ND-fed obesity-prone male 6N mice was significantly lower (p = 0.06 and p < 0.01, respectively) than that in the obesity-resistant male 6J mice of the same age. This evidence concerns the gene TSPAN7 and obesity due to melanocortin 4 receptor deficiency.