Fluorescence images were acquired for 300min and then for an additional 60 min after administration of Z03115(test group), human EGF (positive control), or PBS (vehicle control).Kinetic fluorescence and PAI curves were evaluated to determine theeffects of the ABY-029 dose and EGFR blocking on tumor RA estimation.Nonquantifiable increases in ABY-029 fluorescence in tumor and musclewere observed after in vivo blocking, while PAI producedthe expected decrease in RA. The gene discussed is EGF; the disease is neoplasm.