PPP3R1 and hypertensive disorder: Since Cnb1 deletion in SMCs leads to destabilization of both Cn catalytic subunits expressed in these cells (CnAα and CnAβ) and blocks Ang-II-induced hypertension, we propose that while CnAα mediates the induction of hypertension by Ang-II, CnAβmay be required for its maintenance.