Since LMP1 begins to be induced at the protein level by this timepoint [65], it will be of interest to determine whether TES1 or TES2 signaling increases IMPDH2 activity and XMP abundance at this early timepoint, as well as to define the earliest timepoint post-EBV infection at which LMP1 expression reaches the threshold at which infected cells become sensitized to MPA-driven cell death. Here, EMP2 is linked to Epstein-Barr virus infection.