Notably, only eight CRGs (ATP7A, HR = 1.57, p = 0.033; DBT, HR = 1.6, p = 0.027; DLAT, HR = 1.9, p = 0.0021; DLST, HR = 1.69, p = 0.021; LIAS, HR = 1.68, p = 0.014; LIPT1, HR = 1.95, p = 0.0013; PDP1, HR = 1.82, p = 0.017; FDX1, HR = 1.57, p = 0.031) expressions are associated with pancreatic cancer prognosis, with patients with high levels of these CRGs having a more unfavorable prognosis (Fig 2a-h). Here, ATP7A is linked to familial pancreatic carcinoma.