In addition, when this ACT protocol was tested in mice bearing B16.GFP.gB.luc (IFN-Ilow) tumors, we saw no impact on tumor growth and a significant but moderate increase in overall survival in mice treated with IL-4+ gBT.I cells (19 days) compared to irradiation (16 days) but not mCherry+ gBT.Is (17 days) (Fig. 6, F to H). Here, IL4 is linked to neoplasm.