Extensive research uncovered that photothermal and ferroptosis treatment could induce tumor ICD, characterized by exposure of DAMPs, including calreticulin (CRT) surface translocation, the high-mobility group box 1 protein (HMGB1) secretion, and adenosine triphosphate (ATP) release, which promotes the antitumor immune response by stimulating DC maturation and T cell activation (21, 38). Here, CALR is linked to neoplasm.