To facilitate translational progress, we also outline our planned experimental validation: (i) in vitro assays will be conducted in gastric cancer cell lines AGS and MKN-45 using CCK-8, colony formation, and migration assays, along with Western blot to assess LIMK1 and cofilin signaling; (ii) in vivo studies may utilize an MKN-45 xenograft mouse model and PK testing in BALB/c mice; (iii) collaborations with pharmacology labs are underway to support synthesis, testing, and animal studies. This evidence concerns the gene CFL1 and gastric cancer.