In short-term prognosis studies, baseline serum NfL levels have been associated with worsening of the expanded disability status scale (EDSS) in the first year, number of relapses, and progression of brain atrophy, while in long-term prognosis studies, both baseline and longitudinal measures of NfL levels have been linked to greater cerebral MRI-based brain atrophy [1,3]. Here, NEFL is linked to Brain atrophy.