GPNMB and Alzheimer disease: Furthermore, GPNMB silencing led to a reduction in GPNMB, Beclin-1 and LC3II/ LC3I, and an increase of p62 and Atg4 levels in LINC006720-overexpressed AD cell model (Fig 4B), implying LINC00672 could enhance autophagy by targeting GPNMB in Aβ-stimulated SH-SY5Y cells.