Interestingly, in Figure 5A-C, we unexpectedly found through KEGG pathway enrichment and Venn intersection analysis of SERPINA3-related differentially expressed genes in both the TCGA-prostate cancer database and the SU2C-metastatic prostate cancer database that the IL-17 and TNF signaling pathways were the top two enriched pathways. Here, TNF is linked to Familial prostate cancer.