However, current research on SERPINA3 has indicated that it is upregulated in various types of cancer, such as glioblastoma, colorectal cancer, endometrial cancer, breast cancer, and melanoma, and can participate in tumor progression by regulating signaling pathways, such as PI3K/AKT (7-, 9,14-, , , 18). This evidence concerns the gene AKT1 and melanoma.