Pregnant women with obesity and generalized gingival bleeding exhibited notably higher expression of Cystatin-D (>4-fold), with slight increases in Cystatin-B (1.62-fold), Cystatin-C (1.49-fold), and Cystatin-SN (1.12-fold) compared with G2. The gene discussed is CST4; the disease is obesity due to melanocortin 4 receptor deficiency.