Hypoxia leads toincreased expression of HIF-1α, which upregulates genes involved in tumorprogression.23 Reduced blood flow to the residual tumor and surgicalcavity postoperatively creates a hypoxic environment, which increasesradioresistance.24 Initiating RT before blood flow improves may reducetreatment efficacy. Here, HIF1A is linked to neoplasm.