BRCA1 and breast cancer: Most studies conducted among patients with breast cancer with BRCA1 or BRCA2 pathogenic variants report no significant difference in DRFS, breast cancer-specific survival (BCSS), and OS when comparing BCT with mastectomy.17,20,21,22 Additionally, van den Broek et al23 have reported equivalent survival rates between BCT and mastectomy when specifically analyzing patients with breast cancer with BRCA2 variants.