To explore how A-to-I RNA editing of POLA2 occurs in PCa, ADAR1 or ADAR2 enzyme was transfected into DU145 and LNCap PCa cell lines as it has been proved that ADAR1 and ADAR2 is the main catalytic enzyme for A-to-I RNA editing. Here, POLA2 is linked to posterior cortical atrophy.