Ceria–zirconia NPs [157, 158] and salvianolic acid B NPs [159] have been shown to enhance autophagic flux by promoting TFEB nuclear translocation and improving lysosomal function in kidney models of Fabry disease and acute kidney injury, respectively, suggesting their potential application in obesity-induced kidney disease. This evidence concerns the gene TFEB and obesity due to melanocortin 4 receptor deficiency.