Similarly, Petridis et al. identified germline CDH1 variants in four women with early-onset bilateral LBC, all diagnosed before the age of 50 years, further strengthening the association between CDH1 variants and LBC, even in the absence of a family history of DGC (Petridis et al. 2014). This evidence concerns the gene CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome.