In more detailed analyses for cancer subtypes, no material effect was found for subtypes of colorectal cancers (colon, distal colon, proximal colon, and rectal), lung cancers (squamous cell carcinoma, small cell carcinoma, and adenocarcinoma) and breast cancers (estrogen receptor positive and negative) (Figure 5). The gene discussed is ESR1; the disease is adenocarcinoma.