(1) E‐cadherin localises with both Cortactin and Tks5 close to the ECM surrounding tumour clusters in patient tissues; (2) a pool of E‐cadherin but not P‐cadherin is detected at the invadopodial membrane in the pancreatic BxPC‐3 cell line, pancreatic cancer primary culture and a cell line derived from an inflammatory breast cancer. This evidence concerns the gene SH3PXD2A and familial pancreatic carcinoma.