The main side effects reported were mild hypertrichosis in three patients undertamoxifen treatment (patients 6, 7 and 9), uterine volume enlargement in onepatient during tamoxifen treatment (patient 9), mild biochemicalhyperandrogenemia in one patient during treatment with an aromatase inhibitor(anastrozole 1 mg/day; patient 8), edema in one patient undermedroxyprogesterone acetate treatment (patient 11), and laboratory-detectedpartial adrenal insufficiency in one patient under ketoconazole treatment (200mg/day; patient 13). The gene discussed is CYP19A1; the disease is Adrenal insufficiency.