Conversely, CHIR-AMØ exhibited a reduced expression of the gene sets that characterize lung-resident AMØ in severe COVID-19 ([AMØ1+AMØ2 clusters from EGAS00001005634] [Wendisch et al., 2021], FABP4+ from GSE145926 [Liao et al., 2020], TRAM1 from GSE155249 [Grant et al., 2021]) (Figure 6D and E; Figure 6—figure supplement 2), including key AMØ-specific genes like FABP4 and MARCO (Figure 6E), and similar results were seen upon analysis of AMØ-specific gene sets from other studies (Grant et al., 2021; Melms et al., 2021). Here, FABP4 is linked to COVID-19.