CSF2 and COVID-19: The reprogramming effect of GSK3 inhibition on ex vivo isolated alveolar macrophages bears significant therapeutic implications, particularly in severe COVID-19 cases where pro-fibrotic monocyte-derived macrophages replace GM-CSF-dependent tissue-resident alveolar macrophages (Wendisch et al., 2021; Liao et al., 2020; Delorey et al., 2021).