Notably, the transcriptome of CHIR-Mon exhibited a significant enrichment in MAFB-dependent genes (Figure 5, Figure 5—figure supplement 1) and genes characterizing the MAFB+ pathogenic macrophages in severe COVID-19 (Figure 5—figure supplement 2), whereas it showed an under-representation of genes inhibited by MAFB (Simón-Fuentes et al., 2023; Figure 5F). The gene discussed is MAFB; the disease is COVID-19.