SPP1 and COVID-19: (D) (Upper panel) Gene set enrichment analysis (GSEA) of the gene sets that characterize the monocyte-derived pro-fibrotic macrophage subsets identified in severe COVID-19, namely CD163+/LGMN+ (EGAS00001005634) (Wendisch et al., 2021), MoAM3 (GSE155249) (Grant et al., 2021), and SPP1+ (GSE145926) (Liao et al., 2020), on the ranked comparison of the transcriptomes of CHIR-AMØ vs. DMSO-AMØ.