SPP1 and COVID-19: Furthermore, in agreement with the effect of CHIR-99021, GSK3A/B knockdown enhanced the expression of the MoMac-VERSE macrophage clusters HES1_Mac (#2) and TREM2_Mac (#3) 2 (Figure 4H) as well as the gene sets that define pathogenic pro-fibrotic macrophage subsets in severe COVID-19 ([SPP1+, GSE145926] [Liao et al., 2020], MoAM3 [GSE155249] [Grant et al., 2021] or CD163+/LGMN+ MØ [EGAS00001005634] [Wendisch et al., 2021]) (Figure 4I, Figure 4—figure supplement 1).