Cancer cells can synthesize FAs de novo or acquire them from the surrounding TME.[15] As the expression of acetyl‐CoA carboxylase 1 (ACC1), an essential enzyme in FAs synthesis, showed no difference between Huh7 cells cultured alone and with HSCs, while FAO key enzyme—CPT1A—significantly upregulated after coculturation (Figure3A and Figure S9A, Supporting Information). The gene discussed is CPT1A; the disease is cancer.