Of note, we also found that Kdm6a haploinsufficiency induced skewed myeloid differentiation and progression to CMML‐like disease in zebrafish, in which deregulation of suppressor of cytokine signaling 3a (Socs3a) and aberrant activation of Jak/Stat3 signaling were involved. Here, KDM6A is linked to chronic myelomonocytic leukemia.