For instance, during infection of chronic lymphocytic choriomeningitis virus, KDM6A enhances CD8+ T cell‐mediated antiviral responses independently of H3K27me3 demethylation.[21] In thymocyte development, KDM6A is essential for the differentiation of CD4+ T cells from CD4+CD8+ thymic precursors.[22] Notably, emerging evidence identifies KDM6A as a critical regulator of sex‐specific differences in natural killer (NK) cells, where it governs both cellular fitness and effector functions in a dose‐dependent manner.[23]. Here, CD8A is linked to infection.