KDM6A and hematologic disorder: KDM6A is a pseudoautosomal gene that can escape X inactivation and frequently exhibits haploinsufficient expression in hematologic malignancies when mutated.[13, 23, 41] Previous studies have found that KDM6A haploinsufficiency regulates the numbers and effector functions of lymphoid cells.[14, 23] However, the dosage effect of KDM6A on myelopoiesis remains unclear.