Neutrophil elastase contributes to acute respiratory distress and amplifies pro‐inflammatory cascades,[37, 38] while kallikrein exhibits similar functions and was recently identified as a priming protease for the spike protein of various beta‐coronaviruses.[39, 61] This raises the possibility that Trypstatin may exhibit mild anti‐inflammatory properties, although its effects on these targets are less pronounced due to significantly higher IC50 values compared to its inhibition of transmembrane serine proteases. This evidence concerns the gene KLK4 and Respiratory distress.