PTGS2 and ischemic cardiomyopathy: Hypoxia goes along with the occurrence of ischemic cardiomyopathy and drives lipid peroxidation and cell death of cardiomyocytes.[31, 32] In line with these studies, we found that hypoxia treatment in both H9c2 cells and NCM elevated the level of lipid peroxidation and the expression of Ptgs2 (Figure 2m,n; Figure S2j, Supporting information), whereas dipyridamole robustly reversed these phenotypes.