Mutations rs1061170 and rs10922109 in the CFH gene as well as complement factors C2/CFB, CFI, and C3 are associated with the progression of AMD, HTRA1, and ARMS2 present in retinal tissues and are significantly expressed in the sera of AMD patients, and there is a familial susceptibility to AMD. This evidence concerns the gene HTRA1 and age-related macular degeneration.