The ROC also showed an AUC of 0.6085 for raised serum P16ink4A to detect CIN from healthy controls (Figure 2C) and an AUC of 0.7592 for raised serum P16ink4A to detect CC from healthy controls (Figure 2D). The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.