Additionally, the top 5 biological functional hub genes in NAFLD vs. control (CXCL9, NOS2, SERPINE1, FABP4, and LPL) and NAFLD vs. cirrhosis (AKR1D1, UGT2B17, CYP26B1, LIPC, and DGAT2) groups were identified through PPI analysis among lipid, immune, and metabolism dysregulated genes. The gene discussed is SERPINE1; the disease is Cirrhosis.