Additionally, other genes such as TM6SF2, SAMM50, PARVB, NCAN, PPP1R3B, GCKR, and LYPLAL1 and their variants dysregulate metabolism, immune cell recruitment, and altered signal transduction leading to NAFLD pathogenesis [15, 16]. The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatotic liver disease.