The increase in GCPII-regulated inflammation, and its correlations with calpain-2 and pTau levels are of special interest given the likely roles of inflammatory mechanisms in the common, sporadic form of AD, and the previous finding that levels of pT217-tau correlate with GCPII activity in the dlPFC (Bathla et al., 2023). The gene discussed is CAPN2; the disease is Alzheimer disease.