MAPT and Alzheimer disease: Tau pathology in sporadic Alzheimer’s disease (AD) exhibits a stereotypical progression pattern with neurofibrillary tangles (NFTs) in cortex forming earliest in the rhinal cortices, especially in the entorhinal (ERC) and transentorhinal cortex (Braak and Braak, 1991; Braak and Braak, 1992; Braak and Del Trecidi, 2015; Braak and Del Tredici, 2015; Hyman et al., 1986; Kaufman et al., 2018).