Conversely, a cohort study involving pediatric and young adult B-ALL indicated that high expression of CD58, along with elevated levels of CD123 and CD81, correlated with extended progression-free survival, particularly noting significant overexpression of CD58 in cases with recurrent cytogenetic abnormalities and t (1:19) (45). The gene discussed is CD58; the disease is precursor B-cell acute lymphoblastic leukemia.