CD2 and Hodgkins lymphoma: HL patients exhibit elevated levels of CD58, which interacts with CD2 on CD4+ T cells to create a “rosette” structure, this phenomenon is linked to the CD58-mediated swift and extensive re-localization of CD2 near the IS formation site, accompanied by significant F-actin polymerization, the reduction of CD58 expression or blockade of CD2 diminishes wreath formation and T cell activation (29, 62).