propose that CD58 downregulation correlates with subtypes of DLBCL, indicating that the majority of newly diagnosed DLBCL CD58-positive patients do not belong to the Double-Hit/Triple-Hit subtype, while new-onset cases with a high International Prognostic Index (IPI) are inclined to have CD58 downregulation. This evidence concerns the gene CD58 and diffuse large B-cell lymphoma.