indicated that 20% of DLBCL cases exhibit genetic impairment of the single or double allele CD58 gene, and in cases devoid of CD58 gene defects, over half demonstrate undetectable CD58 protein expression via immunohistochemistry, resulting in diminished tumor cell recognition by Cytotoxic T Lymphocyte and NK cells (68). Here, CD58 is linked to diffuse large B-cell lymphoma.