Nevertheless, diverse inhibitory signaling molecules and tumor escape-related signaling molecules render T cells non-responsive; moreover, forming a rosette with CD58 establishes a physical barrier that obstructs CD8+ T cell and NK cell-mediated killing (29, 65), Thus, high expression of CD58 by HL cells is associated with the promotion of tumorigenesis and development. The gene discussed is CD8A; the disease is neoplasm.