Research on systemic and cutaneous Dual Specificity Phosphatase-22 (DUSP-22) rearrangements in Anaplastic Lymphoma Kinase (ALK)-negative Anaplastic Large Cell Lymphoma (ALCL) has demonstrated positive CD58 expression, correlating with immune identification of the tumor and a favorable prognosis (76). The gene discussed is ALK; the disease is anaplastic large cell lymphoma.