When the proband presented with CNO/CRMO and unexplained hypercalcemia, he underwent clinical trio rapid whole‐genome sequencing, which did not identify additional variants, including variants in genes implicated in monogenic inborn errors of immunity and CNO/CRMO, including IL1R1, IL1RN, LPIN2, FBLIM1, and NLRP3 [31]. This evidence concerns the gene NLRP3 and chronic recurrent multifocal osteomyelitis.