Additionally, MO supplementation suppressed CKD-induced ferroptosis and ferritinophagy by regulating the protein expression of SLC7A11 glutathione peroxidase 4, prostaglandin-endoperoxide synthase 2, human palmitoyl-CoA ligase, NADPH oxidase 4, 4-hydroxynonenal, transferrin receptor, heme oxygenase-1, nuclear receptor coactivator 4, beclin-1, microtubule-associated proteins 1A/1B light chain 3B, and kallikrein-related peptidase 4. The gene discussed is NOX4; the disease is chronic kidney disease.