IGFBP5 and myocardial infarction: However, ISL or sh-IGFBP5 significantly reduced infarct size compared to the MI/R group (Sham v. s. MI/R, p < 0.0001; sh-Scramble v. s. sh-IGFBP5, p = 0.0176; oe-Scramble v. s. oe-IGFBP5, p = 0.0007; oe-IGFBP5 v.