EGFR and non-small cell lung carcinoma: So it is well-established that the inhibition of phosphorylation at these key sites effectively disrupts EGFR signaling, thereby the viability and proliferation of NSCLC cells (Tang et al., 2021; Wang et al., 2018; Ma et al., 2020; Liu and Gao, 2020; Jiang et al., 2017; Qin et al., 2020; Tang et al., 2016; Perera et al., 2005; van Rosenburgh et al., 2022), Also, inhibition of phosphorylation of EGFR_TK was reported after treatment with plant-derived bioactive metabolites, like curcumin (Starok et al., 2015; Zhen et al., 2014), resveratrol (Wang et al., 2020), etc.