While previous studies have highlighted TP’s suppression of IL-17A via Th17 inhibition or NF-κB signaling in conditions such as liver fibrosis and rheumatoid arthritis (Horitani and Shiojima, 2024; Jiang et al., 2025), our work uncovers a previously unrecognized mechanism: TP’s regulation of the Wnt5a/β-catenin axis in keratinocytes. Here, WNT5A is linked to rheumatoid arthritis.