TNF and neoplasm: Additionally, GPX4 knockdown in tumor tissues was found to promote the secretion of pro-inflammatory factors (e.g., IL-1β, IL-6, IL-12, IFN-γ, and TNF-α) and inhibit the secretion of anti-inflammatory factors (e.g., IL-10 and TGF-β) in the blood, which is closely associated with tumor immune activation.