Notably, robust suppression of tumor growth was observed in OE-NC tumors following treatment with RGX104 in combination with anti-PD-L1, as well as in tumors overexpressing Apoe treated with anti-PD-L1, when compared to OE-NC tumors treated with anti-PD-L1 alone (Figure 8D). The gene discussed is CD274; the disease is neoplasm.