TP53 and diabetic cardiomyopathy: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis further implicated DDR, revealing enrichment in the "p53 Signaling Pathway." Additionally, pathways related to cardiac function ("Diabetic Cardiomyopathy," "Cardiac Muscle Contraction") and cellular metabolism ("Oxidative Phosphorylation," "Carbon Metabolism," "Glycolysis / Gluconeogenesis") were significantly enriched (Figure 4F).