Following the identification of DNA Damage Response (DDR) pathway activation and the consistent upregulation of key DDR-associated genes, including YAP1, PRKDC, XRCC5, and XRCC6, across human and murine septic heart tissue datasets (GSE79962, Figure 6A; GSE267388, Figure 6B), we investigated the clinical relevance of these findings in human sepsis. This evidence concerns the gene PRKDC and Sepsis.