Our results demonstrated that Ampk-KO tumor cells up-regulated the expression of PD1 and TIM3 on CD8+ T cells, which were inhibited by STS, while Pdl1-KO tumor cells reduced the elevated expression of PD1 and TIM3 on CD8+ T cells induced by Ampk-KO (Figure S2C-S2D). This evidence concerns the gene PDCD1 and neoplasm.