We tested 8 AML patients' primary samples with baseline BH3 toolkit (Supplementary Figure 3C) and we observed various BH3 dependencies profiles, with some patients having mild BCL-2 and MCL-1 dependencies (Patient 3, 6, 7, and 8) or low BCL-2 and BCL-XL dependencies for patient 5. Here, MCL1 is linked to acute myeloid leukemia.