Specifically, NET-associated NE and Matrix Metalloproteinase 9 (MMP9) possess the capacity to cleave laminin proteins; this action can reawaken dormant breast cancer cell populations from both human origins and murine models, fostering lung metastasis through activation of the Integrinα3β1-FAK-ERK-MLC2 signaling cascade 71. The gene discussed is MMP9; the disease is breast cancer.