The development of HCC is driven by overexpression or dysregulation of growth factors and their receptors such as EGFR, IGFR, VEGFR, HGFR (c-MET), PDGFR, and FGFR, leading to alterations in critical signaling pathways such as Ras/Raf/MEK/ERK, JAK/STAT, PI3K/AKT/mTOR, TGF-β, NF-κB and Wnt/β-catenin (Höpfner et al., 2006; Tripathy et al., 2018). Here, EGFR is linked to hepatocellular carcinoma.