littorale, containing swertiamarin, is known to affect liver fibrosis via transforming-growth factor (TGF-β), rejuvenate pancreatic islets, regulate insulin signaling, β-adrenergic (β-AR) system, alleviation of oxidative stress, expression of peroxisome proliferator-activated receptors (PPARs) towards lipid oxidation, restoration of sodium/potassium channels (Na+/K+ ATPase), prevent apoptosis of cardiomyocytes, and ECM homeostasis. This evidence concerns the gene INS and Hepatic fibrosis.