NPPB and Hyperglycemia: To substantiate the existence and outcomes of hyperglycemia and CH in experimental rats, the levels of blood HbA1c (Figure 6), serum NT-pro BNP (Figure 7), and LDH (Figure 8) were also monitored in the present study, all of which are associated with defective mitochondrial metabolism (Lichscheidt et al., 2022).