GPX4 and osteoporosis: Ma et al. (2020) reported that melatonin reduces the level of ferroptosis in type 2 diabetes patients with osteoporosis by activating the Nrf2/HO-1 pathway. Yang et al. (2022c) found that Maresin1 prevented ferroptosis-induced liver damage by decreasing ROS generation and Nrf2/HO-1/GPX4 activation.