Phototransduction in both PDE6B and RDH12-AD retinal organoid models reveal downregulation of ARR3, CNGA3, GNAT2, OPN1LW, PDE6C, PDE6H, RGS9BP, and RPGRIP1 (Gao et al., 2020). The gene discussed is PDE6B; the disease is Alzheimer disease.