RDH12 and Alzheimer disease: RDH12 is a key example; ∼80 biallelic pathogenic variants account for up to 10% of LCA (Sarkar and Moosajee, 2019), but four rare cases of autosomal dominant (AD) late-onset retinitis pigmentosa (RP) have been reported (Fingert et al., 2008; Muthiah et al., 2022; Sarkar et al., 2020).