Hence, in this study, we generated and characterized retinal organoid models differentiated from human induced pluripotent stem cells (HiPSC) derived from a patient with heterozygous pathogenic frameshift c.759del p.(Phe254Leufs*24) in RDH12, who was affected with dominant mild, late-onset RP (RDH12-AD) (Sarkar et al., 2021; Sarkar et al., 2020). The gene discussed is RDH12; the disease is Alzheimer disease.